Showing posts with label .B.PHARMACY 6TH SEM COMPLETE SYLLABUS DOWNLOADPHARMACY SYLLABUS IN PDF. Show all posts
Showing posts with label .B.PHARMACY 6TH SEM COMPLETE SYLLABUS DOWNLOADPHARMACY SYLLABUS IN PDF. Show all posts
PHAR. CHEMISTRY -VI PY-503 SYLLABUS
Introduction to medicinal chemistry
- Principles of drug discovery: Basic principles of medicinal chemistry,physicochemical and steric aspects (optical, geometric and bioisosterism) of drug molecules and biological actions.
- Receptors and drug action: Receptor theories, affinity, receptor and biologic response.
- Drug metabolism: Phase I (biotransformation reactions), phase II (conjugation reactions), factor affecting drug metabolism.
- Prodrugs and drug latentiation: Basic concepts, prodrug of functional groups, bioprecursor prodrugs, chemical delivery system. Classification and mode of action, uses, structure activity relationship including physicochemical, steric aspects and resents advances in research of the following categories of drugs:
- Drugs affecting neurotransmission
- Drugs affecting cholinergic neuro transmission: Neuro chemistry and stereochemistry of acetylcholine, acetylcholine mimetics-muscarinic agonists,acetlycholinesterase inhibitors, acetylcholine antagonists-muscarinic anatagonists, nicotinc antagonists-neuromuscular blocking agents, ganglionic blocking agents.
- Drugs affecting adrenergic neurotransmission: Neurochemistry and stereochemistry of norepinephrine, sympathomimetic agents, sympatholytic agents, drugs affecting catecholamine biosynthesis, drugs affecting catecholamine storage and release, ergot alkaloids, xanthine bronchodilators
- Drugs affecting serotonergic neurotransmission: Neurochemistry and stereochemistry of serotonin, 5-HT agonists, 5-HT antagonists.
- Local anesthetics: Molecular mechanism of action, chemical aspects.
- Drugs affecting immune systems
- Non-steroidal anti-inflammatory agents: Chemistry of chemical mediators of inflammation (prostaglandins, thromboxanes, prostacyclin and leukotrienes), antipyretic analgesics.
- Antihistaminics and related antiallergics: Neurochemistry and stereochemistry of histamine, inhibitor of histamine release (mast cell stabilizers), inhibitors of released histamine, dual acting antihistaminics; H2 antagonists, H3 antagonists.
LIST OF PRACTICALS:
(Minimum fifteen experiments should be performed in the semester. Student should aware with safety parameters and handling of chemicals related to following experiments)
- Synthesis and characteriazation of Tropenone from Maleyde aldehyde.
- Synthesis and characteriazation of Scopolamine from Tropenol.
- Synthesis and characterization of chlorzoxazone from 2-amino-4-chlorphenol.
- Synthesis and characterization of Clemastine.
- Synthesis and characterization of Tripelennamine.
- Synthesis and characterization of Oxyphenbutazone.
- Synthesis and characterization of trihexyl phenylidine.
- Synthesis and characterization of Aspirin from salicylic acid.
- Synthesis and characterization of Benzimadazole from benzyl chloride.
- Synthesis and characterization of Sulphonilamide from Aniline.
- Synthesis and characterization of Paracetamol from Para amino phenol.
- Synthesis and characterization of Ibuprofen from isobutyl benzene.
- Synthesis and characterization of Antipyrine
- Synthesis and characterization of Phenyl benzoate.
- Synthesis and characterization of Benzenilide.
- Synthesis and characterization of Phenindione.
- Synthesis and characterization of Methyl pyrazolone.
BOOKS RECOMMENDED:
- Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia.
- Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons, New York.
- Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press, Oxford.
- Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicinal and Pharmaceutical Chemistry, J.Lippincott Co., Philadelphia.
- Nogrady, T., Medicinal Chemistry-A Biochemical Approach, Oxford University Press, New York, Oxford.
- Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi.
- Patrick, G., An Introduction to Medicinal Chemistry, Scientific Distributors, Mumbai.
- Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs.
- Parimoo, P., Text Book of Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.
- Thomas, G., Introduction to Medicinal Chemistry, CBS Publishers and Distributors, New Delhi
META TAGS:-RGPV B.PHARMACY 6TH SEM SYLLABUS I RGPV B.PHARMACY 6TH SEM PHARMACEUTICAL ANALYSIS-II SYLLABUS I DOWNLOAD B.PHARMACY 6TH SEM PAPERS I RGPV B.PHARMACY PY-602 SYLLABUS I PHARMACEUTICAL ANALYSIS SYLLABUS I B.PHARMACY COMPLETE SYLLABUS I RGTU B.PHARMACY 6TH SEM SYLLABUS I RGPV B.PHARMA SYLLABUS I B.PHARMACY 6TH SEM RGPV SYLLABUS I DOWNLOAD RGPV B.PHARMACY 6TH SEM PHARMACEUTICAL ANALYSIS PAPERS I PHARMACEUTICAL ANALYSIS-II PAPERS I B.PHARMACY 6TH SEM COMPLETE SYLLABUS DOWNLOAD
The theoretical aspects, basic instrumentation, elements of interpretation of spectra and pharmaceutical application of the following analytical techniques –
- Chromatography: Paper Chromatography TLC, GLC, HPTLC and HPLC.
- Ultraviolet and visible spectrophotometry: Beer-lambart law, electronic transitions, instrumentation, methods, chemical derivatisation, structural analysis,applications.
- Infra red spectrophotometry & FT-IR: Introduction, Theory, instrumentation,interpretation of spectra, its advantages and applications in structure elucidation.
- Fluorimetry.
- Mass Spectroscopy: Introduction, ionization techniques, mass analyzers,fragmentation rules, instrumentation, the mass spectrum & its applications.
- NMR Spectroscopy: Introduction, continuous-wave (CW) NMR spectrometry, pulsed fourier transform spectrometry,chemical shift, pin coupling,spin decoupling & its applications.
- Atomic Absorption.
- X- Ray Diffraction.
- Flame Photometry.
- Immunoassay techniques: Enzymes & radioimmunoassay techniques, theory, methods & its applications.
BOOKS RECOMMENDED:
- Svehla, G. Vogel’s Text Book of Micro and Semi Micro Qualitative Inorganic Analysis, Orient Longman, Hyderabad.
- Beckett, A.H. and Stenlake, J.B., Practical Pharmaceutical Chemistry, TheAthlone Press of the University of London.
- Chatten, L.G., Text Book of Pharmaceutical Chemistry, Marcel Dekker, NewYork.
- Connors, K,.A., A Text Book of Pharmaceutical Analysis, Wiley Interscience,New York.
- Higuchi, J. and Hansen E.B., Pharmaceutical Analysis, Interscience Publisher John Willey and Sons, New York, Sydney.
- Silverstein,R.M., Bassier, G.C., and Morril,T.C., Spectrophotometric Identification of Organic Compounds, John Wiley and Sons Inc.
- Willard, Merritt and Settle, Instrumental Methods of Chemical Analysis,CBS Publisher and Distributors, New Delhi.
- Ewing, G.W., Instrumental Methods of Chemical Analysis,.
LIST OF PRACTICALS :
- Determination of solvent cut off value of different solvents.
- Study of effect of various solvents on spectral features of any drug.
- Perform the quantitative spectrophotometric estimation of drug by single point method.
- Perform the quantitative spectrophotometric estimation of drug by calibration curve method.
- Perform the quantitative spectrophotometric estimation of drug by standard absorptivity method.
- Simultaneous quantitative spectrophotometry estimation of two drugs by simultaneous equation method.
- Simultaneous quantitative spectrophotometric estimation of two drugs by dual wavelength method.
- Simultaneous quantitative spectrometric estimation of two drugs by derivative spectroscopy.
- To determine the drug content of given tablet formulation
- Interpretation of given IR spectra.
- Quantitative estimation of alprazolam (Any drug) by RP-HPLC.
- Simultaneous quantitative estimation of torsemide and spironolactone ( Combination of two drugs) by RP-HPLC.
- Acid and alkaline stress degradation study of any drug.
- Photo and thermal stress degradation study of any drug.
- Oxidative stress degradation study of any drug.
