PHARMACEUTICAL CHEMISTRY-III SYLLABUS
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META TAGS:- RGPV B. PHARMACY SYLLABUS I RGPV B. PHARMACY PY 203 SYLLABUS I ORGANIC CHEMISTRY 1 SYLLABUS I RGTU SYLLABUS DOWNLOAD I DOWNLOAD RGPV B. PHARMACY SYLLABUS I RGTU PHARMACEUTICAL CHEMISTRY-III SYLLABUS I B.PHARMACY 2ND SEM ORGANIC-I SYLLABUS I DOWNLOAD PHARMACEUTICAL CHEMISTRY-III SYLLABUS I DOWNLOAD RGTU B.PHARMACY 2ND SEMESTER PY-203 SYLLABUS I RGTU B.PHARMACY SYLLABUS I B.PHARMACY 2ND SEM PAPERS I B.PHARMACY 2ND SEM PREVIOUS YEAR PAPERS I RGPV B.PHARMACY 2ND SEM SYLLABUS I PHARMACEUTICAL CHEMISTRY-III SYLLABUS
PHARMACEUTICAL CHEMISTRY-III PY-203 (ORGANIC-I) SYLLABUS
UNIT-I
Structure and Properties:Electronegativity,Polarity, Resonance;Electrophiles/Nucleophiles, Orbitals, π-Bonds, Hybridization and Shape, Isomerism, Polarity, Intermolecular Forces, isotope effects and isotopic labelling.

UNIT-II
Reactive Intermediates: Stability and reactivity of Radicals, Cations, Anions, Nitrene and Nitrenium ion

UNIT-III
Stereochemistry:Stereo-isomerism, classification and Nomenclature,Optical activity, Chirality, R/S Classification of Chiral Carbons. Miscellaneous Stereochemistry, Diastereomers; Racimic modification, Resolution of racimic mixtures.

UNIT IV
Hydrocarbons: Alkanes and cycloalkanes:Nomenclature, Physical and chemical properties of alkanes, Conformations and Stability of Acyclic Alkanes and Cycloalkanes.  
Alkenes and alkynes:Nomenclature,Physical and Chemical properties of alkenes, isomerism, and general methods of preparation. 
Aromatic hydrocarbons:Benzene and its homologues (Polynuclear compounds), nomenclature,sources of aromatic hydrocarbons, structure of benzene, chemical reaction of benzyne-mechanism and SNAr Mechanism of nucleophilic substitution. Directive influence of substituents and their effect on reactivity. 
Dienes and the Allyl system: Conjugation, Reactivity.

UNIT-V
Organic compounds with functional groups containing halogens (X): Nomenclature, Structure, Properties, Reactivity of Alkyl Halides (haloalkanes and haloarenes): The SN2 and SN1 Substitution Reaction, The E1 and E2 Elimination Reactions, Substitution vs. Elimination reaction, reactivity of C-X bond in haloalkanes and haloarenes

UNIT VI
Organic compounds with functional groups containing oxygen (Part I-): Alcohols: Nomenclature, Synthesis, reactivity of different Alcohols; conversion of Alcohols to Tosylates or Halides.
Phenols: Nomenclature, methods of preparation, physical and chemical properties; chemical reactivity of phenols in electrophilic substitutions, acidic nature of phenol. 
Ethers: electronic structure, structure of functional group, nomenclature,important methods of preparation, physical and chemical properties, some commercially important compounds.

UNIT-VII
Organic compounds with functional groups containing oxygen (Part II): Aldehydes and ketones : Electronic structure of carbonyl group, nomenclature, important methods of preparation, physical properties and chemical reactions, relative reactivity of aldehydic and ketonic groups, aldol condensation. nucleophilic addition reaction to >C=O groups.
Carboxylic acids: Electronic structure of -COOH, Nomenclature, important methods of preparation, physical properties and effect of substituents on α-carbon on acid strength, chemical reactions. 
Derivatives of carboxylic acids: Electronic structure of acid chloride, acid anhydride, ester and amide groups, Nomenclature, important methods of preparation, comparative reactivity of acid derivatives.

UNIT-VIII
Organic Compounds with functional group containing Nitrogen: Structure, Nomenclature of Amino and Diazo Compounds. 
Amines: Primary, secondary and tertiary amines, a general awareness, important methods of preparation, physical properties, basic character of amines, chemical reactions. 
Diazonium salts:Preparation, chemical reaction and uses of Benzene diazonium chloride. Some commercially important nitrogen containing carbon compounds(Aniline, TNT)

LIST OF PRACTICALS:
  • Purify the given organic compounds by distillation.
  • Purify the given organic compounds by recrystillazation.
  • Introduction to the use of stereo models.
  • Synthesis, Purification, Characterization (by using Solubility, Melting Point,T.L.C. and percentage purity) of organic compounds and percent yield calculations of the following compounds:
  • a) 2, 4, 6-trinitro phenol (Picric acid) from phenol
  • b) Iodoform from ethyl alcohol
  • c) 2, 4, 6-tribromoaniline from aniline
  • d) 2, 4, 6-tribromo phenol from phenol
  • e) Phenylbutazone from phenol
  • f) Benzanilide from aniline
  • g) Phthalidimide from phthalic anhydride
  • h) Thiourea
  • i) Phenyl urea
  • j) Flourescein
  • k) Methly orange
  • l) Methly red
BOOKS RECOMMENDED:
  • Organic Chemistry, R.T. Morrison and R.N. Boyd, 6th Edition, New York.
  • Organic Chemistry, T.W.G. Solomons, 8th Edition, John Wiley & Sons, Inc
  • Advanced Organic Chemistry, J. March, Reaction Mechanisms and Structure, John Wiley and Sons, N.Y.
  • Mechanisms and structure in Organic Chemistry, E.S. Gould, Hold Rinchart and Winston, New York.
  • Advanced Organic Chemistry, Reaction Mechanisms, Bernard Miller, 2nd edition, Pearson education Ptc. Ltd. Singapore.
  • Named Organic Reactions, Thomas Lane & Andreas Plagens, 2nd edition, John Wiley and Sons, N.Y).
  • Organic Chemistry Finar Vol-1 & 2.
  • Structure and Mechanism in Organic Chemistry, Ingold, C. K., Cornell University.
  • Stereochemistry of Carbon Compounds, Eliel, E.L., McGraw Hill, New York.
  • Elements of Stereochemistry, Eliel, E.L., Wiley, New York.

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