META TAGS:- RGPV B. PHARMACY SYLLABUS I DOWNLOAD RGPV B. PHARMACY 6TH SEM SYLLABUS I RGPV B. PHARMACY PHARMACEUTICAL CHEMISTRY SYLLABUS I RGPV MEDICINAL CHEMISTRY-II SYLLABUS I RGTU B.PHARMACY 6TH SEM SYLLABUS I DOWNLOAD RGPV B.PHARMACY 6TH SEM SYLLABUS I RGTU PHARMACEUTICAL CHEMISTRY SYLLABUS I PY-603 SYLLABUS I RGPV PY-603 PREVIOUS YEAR PAPERS I RGTU B.PHARMACY 6TH SEM COMPLETE SYLLABUS I B.PHARMACY 6TH SEM PAPERS I B.PHARMACY SYLLABUS FOR 6TH SEM I RGPV B.PHARMACY 6TH SEM PAPERS IN PDF I RGPV B.PHARMACY 6TH SEM COMPLETE SYLLABUS I B.PHARMACY 6TH SEM PRACTICAL LIST I BOOKS FOR RGPV B.PHARMACY 6TH SEM I PRACTICAL LIST OF RGPV B.PHARMACY 6TH SEM
PHARMACEUTICAL CHEMISTRY – PY 603 SYLLABUS
( I ) Classification and mode of action,uses,structure activity relationship including physico chemical, steric aspects and recent advances in research of the followingb categories of drugs:
(A) Drug Acting on CNS
(A) Drug Acting on CNS
- General Anesthetics: Stages of Anesthesia , Pharmacokinetic Principles, Theories of the mechanisms.
- Hypnotics and Sedatives : Testing and developments of new Hypnotics.
- Antiscizure agents: Drugs effective against partial and generalized tonicclonic scizure.
- Opiod Analgesics : Endogenous opioid peptides and their physiologic functions, Neurobiology of drug abuse and addiction.
- Antiparkinsonian and Spasmolytic agents : Pharmacotherpy of Parkinsonsdisease.
- Hallucinogens, Stimulants, and related drugs of Abuse.
- Psychopharmacological Agents: Antipsychotic agents, Antidepressants,Anxiolytics.
(B) Drug Acting on GIT :
- Laxative
- Antimalarial
- Anti spasmodic
- Anti ulcers Drugs.
(C) Drug Acting on Hormonal System:
- Insulin and oral Hypoglycemic agents: Etiology of Diabetes, Biochemistry and Pathogenesis of Diabetes, Production of Insulin.
- Adrenocorticoids: Mechanism of steroid Hormone action, Development of Adrenocorticoid drugs.
- Sex Hormones: Male sex Hormones, Female sex Hormones.
- Thyroid and Antithyroid agents : Biochemistry and Physiology of Thyroid Hormones, Biosynthesis of Thyroid Hormones.
(D) Vitamins
( II )Principles of Drug Design (Theoretical Aspects).Scientific Aspects of Drug Discovery, Preclinical Development, Mechanism based Approaches (Computer Aided Drug Design and Molecular Modeling)
BOOKS RECOMMENDED:
- Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia.
- Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons,New York.
- Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press,Oxford.
- Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicinal and Pharmaceutical Chemistry, J.Lippincott Co.,Philadelphia.
- Nogrady, T., Medicinal Chemistry-A Biochemical Approach, Oxford University Press, New York, Oxford.
- Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi.
- Patrick, G., An Introduction to Medicinal Chemistry, Scientific Distributors, Mumbai.
- Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs.
- Parimoo, P., Text Book of Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.
- Thomas, G., Introduction to Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.
LIST OF PRACTICALS :
- Synthesis and Characterization of Methylphenobarbital from Urea.
- Synthesis and Characterization of Barbital from Urea.
- Synthesis and Characterization of Nikethamide from Nicotinic acid.
- Synthesis and Characterization of Pantaprazol.
- Synthesis and Characterization of Diclofenamide.
- Synthesis and Characterization of Phenobarbitone.
- Synthesis and Characterization of Phenothiazine.
- Synthesis and Characterization of Furosemide from 2,4 dichloro-benzoic acid.
- Synthesis and Characterization of Levodopa from Vanillin.
- Synthesis and Characterization of Sulfalene from p-aminobenzene sulphonyl chloride.
- Synthesis and Characterization of Thioridazine.
- Synthesis and Characterization of Chlorpromazine.
- Synthesis and Characterization of Benorilate.
- Synthesis and Characterization of Parbanic acid.
- Estimation of Na+, K+, Ca++ ions using flame photometry.
- To perform the QSAR Analysis by Free Wilson Approach.
- To determine the regression coefficients for a series by using Hansch and Free Wilson Approach.
- To determine the correlation between physiochemical properties and biological activity for a series by using Hansch analysis.
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