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PHARMACOLOGY- I (THEORY) – PY 405 SYLLABUS
UNIT-I
General PharmacologY:Introduction to pharmacology, sources of drugs, dosage forms and routes ofadministration, mechanism of action, combined effects of drugs, factors modifying drug action, tolerance and dependence, pharmacogenetics .
Absorption, distribution and excretion of drugs, principle of basic and clinical pharmacokinetics adverse drug reactions and treatment of poisoning, ADME drug interaction, bioassay of drugs and biological standardization, discovery and development of new drugs. Introduction to clinical trials.
UNIT-II
Pharmacology of Peripheral Nervous System:Neurohumoral transmission (autonomous and somatic) Parasympathomimetic,parasympatholytic,sympathomimetics,sympatholytics,neuron blocking agents.Neuromuscular blocking agents.Local anaesthetic agents UNIT-III
Autocoids:Histamine, bradykinin 5- HT and their antagonists.Prostaglandins, leukotrienes and platelet activating factors.UNIT-IV
Analgesic,Antipyretic,Anti-inflammatory and Anti-Gout Drugs:Drugs acting on Respiratory System and Pathophysiology of respiratory system:a. Anti-asthmatic drugs including bronchodilators
b. Anti-tussives and expectorants
LIST OF PRACTICALS:
- Introduction to Experimental Pharmacology and various regulatory authorities.
- Study of common laboratory animals and anesthetics used in animal studies.
- Study of various routes of drug administration in experimental animals.
- Preparation of various physiological salt solution and set up of isolated rat ileum preparation.
- Study the effects of various agonists and antagonists on isolated rat ileum preparation.
- Plot dose response curve of choline using isolated gunea pig ileum preparation.
- Plot dose response curve of histamine using isolated guinea pig ileum preparation.
- Study the effect of autonomic drugs mydriatic and miotic on rabbit eye.
- Study the effect of local anesthetics on rabbit eye.
- Study the peripheral analgesic activity of indomethacin using writhing test on mice.
- Study anti- inflammatory activity of indomethacin using rat paw edema paradigm.
- Study the neuromuscular effect of d-tubocurarine/ succinyl choline using rotarod apparatus.
REFERENCE BOOKS:
- Satoskar, R.S. and Bhandarkar, S.D., Pharmacology and Pharmacotherapeutics.
- Tripathi, K.D., Essentials of Medical Pharmcology.
- Kulkarni, S.K., Handbook of Experimental Pharmacology, Vallabh Prakashan, New Delhi.
- Crossland, J and Thomson, J.H., Essential of Pharmacology, Harper and Row,Publishers, New York.
- Craig, C.R. and Stitzel, R.R., Modern Pharmacology, Little Brown and Company.
- Rang, M.P. , Dale, M.M. and Riter, J.M., Pharmacology, Churchill Livingstone.
- Paul, L., Principles of Pharmacology, Chamman and Hall.
- Herfindal, E.T. and Hirschman, J.L., Clinical Pharmacy and Therapeutics,William and Wilkins.
- Katzung, B.G., Basic and Clinical Pharmacology, Prentice Hall International.
- Hardmen, J.G., Limbired, L.E., Molinoss, P.B., Ruddon, R.W. and Gil, A.G., Goodman and Gillman’s The Pharmacological basis of Therapeutics, Pergamon Press.
- Satoskar, R.S. and Bhandarkar, S.D., Pharmacology and Pharmacotherapeutics.
- Tripathi, K.D., Essentials of Medical Pharmcology.
- Kulkarni, S.K., Handbook of Experimental Pharmacology, Vallabh Prakashan, New Delhi.
- Crossland, J and Thomson, J.H., Essential of Pharmacology, Harper and Row, Publishers, New York.
- Craig, C.R. and Stitzel, R.R., Modern Pharmacology, Little Brown and Company.
- Rang, M.P. , Dale, M.M. and Riter, J.M., Pharmacology, Churchill Livingstone.
- Paul, L., Principles of Pharmacology, Chamman and Hall.
- Herfindal, E.T. and Hirschman, J.L., Clinical Pharmacy and Therapeutics, William and Wilkins. Katzung, B.G., Basic and Clinical Pharmacology, Prentice Hall International.
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