PHARMACEUTICAL CHEMISTRY IV (ORGANIC CHEMISTRY II) - PY- 303
1. Photochemistry and Pericyclic reaction
- Theory-energy transfer-characteristics of photoreactions –typical photoreaction.Electrocyclic reaction–sigmatropic rearrangement cycloaddition reactions.Neighboring group effect, Catalysis by transition metal complexes.
2. Heterocyclic Chemistry
- Nomenclature of Heterocycles:Nomenclature (Hantzsch-Widman system) for monocyclic (three, four, five, six and large membered), fused and bridged heterocycles.
- Aromatic and Non-aromatic Heterocycles:General chemical behaviour of aromatic heterocycles, classification (structural type),Heteroaromatic reactivity and tautomerism in aromatic heterocycles, Strain–bond angleand torsional strains and their consequences in small ring heterocycles
- Synthesis, chemical reactivity and medicinal application of the following heterocycles
- Three and four-membered heterocycles: aziridines and azetidines
- Five membered hetero cycles: Furan, thiophen, pyrrole, pyrazole, oxazole, imidazole,triazole.
- Benzo-Fused Five-Membered Heterocycles: Benzimidazole, benzthiazole and benztriazole.
- Six-Membered Heterocycles with One, Two or More Heteroatoms: Pyridine and Pyrimidine.
- Fused heterocycles: Quinoline, isoquinoline, acridine, coumarins.
3. Organic Compounds with functional group containing nitrogen
- Structure, nomenclature of nitro and cyano compounds.
- Nitro compounds: Important methods of preparation, physical properties and chemical reactions.
- Cyanides and isocyanides: preparation, physical properties and chemical reactions.
4. Structure, Nomenclature and reactivity of Sulphur containing compounds
LIST OF PRACTICALS :-
- Synthesis and Characterization of – Benzthiazole.
- Synthesis and Characterization of Quinoline.
- Synthesis and Characterization of Benzimidazole.
- Synthesis and Characterization of triazoles.
- Synthesis and Characterization of pyrimidines.
- Synthesis and Characterization of acridines.
- Synthesis and Characterization of cuomarins.
- Synthesis and Characterization of azipine.
- Synthesis and Characterization of oxazole.
- Synthesis and Characterization of picric acid.
- Synthesis and Characterization of 3- nitro benzaldyhyde.
- Synthesis and Characterization of 2 – mercapto oxadiazole.
- Synthesis and Characterization of thiazolidinedione.
- To perform the reduction of aromatic nitro group 2- amino group (Nitro benzene to aniline, nitrobenzoic acid to amino benzoic acid, etc)
BOOKS RECOMMENDED:
- The Chemistry of Heterocycles, T. Eicher and S. Hauptmann, Thieme.
- Heterocyclic Chemistry, J.A. Joule, K. Mills and G.F. Smith, Chapman and Hall.
- Heterocyclic Chemistry, T.L. Gilchrist, Longman Scietific Technical
- Contemporay Heterocyclic Chemistry, G.R. Newkome and W.W. Paudler, Wiley-Inter Science.
- Heterocyclic Chemistry Vol. 1-3, R.R. Gupta, M. Kumar and V. Gupta, Springer Verlag
- An introduction to the Heterocyclic Compounds, R.M. Acheson, John Wiley
- Comprehensive Heterocyclic Chemistry, A.R. Katritzky and C.W. Rees, eds. Pergamon
- Natural Products: Chemistry and Biological Significance, J.Mann, R.S. Davidson, J.B.
- Hobbs, D.V. Banthrope and J.B. Harborne, Longman, Essex.
- Organic Chemistry, Vol 2, I.L. Finar, ELBS.
- Stereoselective Synthesis: A Practical Approach, M. Nogradi, VCH
- Name Reactions in Heterocyclic Chemistry by J. J. Li. Wiley, 2005.
- Molecular Photochemistry, N.J. Turro, W.A. Benjamin
- Introductory Photochemistry, A. Cox and T. Camp, McGraw Hill
- Photochemistry, R.P. Kundall and A. Gilbert, Thomson Nelson
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